Clin Endosc.  2014 Nov;47(6):564-567. 10.5946/ce.2014.47.6.564.

Successful Treatment of a Gastric Plasmacytoma Using a Combination of Endoscopic Submucosal Dissection and Oral Thalidomide

  • 1Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.
  • 2Department of Pathology, Chungnam National University School of Medicine, Daejeon, Korea.


We report a rare case of a gastric plasmacytoma treated with endoscopic resection and oral thalidomide therapy. A 70-year-old man was admitted to our hospital with indigestion. He had no specific medical history and unremarkable laboratory results. Gastroendoscopic findings revealed a focal, erythematous, flat elevated lesion in the anterior wall of the stomach antrum. A biopsy revealed atypical lymphocytes. Endoscopic submucosal dissection (ESD) with an insulation-tipped knife was performed 45 days after diagnosis. Radiological and hematological evaluations, including a bone marrow biopsy, were performed and showed no involvement of other organs. The patient was diagnosed with extramedullary gastric plasmacytoma. Follow-up gastroendoscopy was performed three times during a 2-year period and showed nonspecific ESD scarring. The patient's condition was found to be stable.


Endoscopic submucosal dissection; Gastric plasmacytoma; Extramedullary plasmacytomas
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