J Rhinol.  2000 Nov;7(2):149-153.

Inhibition of Murine Allergic Response by Monoclonal Interleukin-4 Receptor Antibody

Affiliations
  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea. chulhee@snu.ac.kr
  • 2Department of Otolaryngology, Sanggye Paik Hospital, Inje University, Seoul, Korea.

Abstract

BACKGROUND AND OBJECTIVES: Several strategies were used to control the IgE production by interfering the functional activities of IL-4. However, most of them revealed limited effects to reduction of allergic response. This study was aimed to investigate the effects of interleukin-4 receptor (IL-4R) antibody on allergic response in animal model of allergic rhinitis.
MATERIALS AND METHODS
Male BALB/C mice were sensitized with intraperitoneal injection of ovalbumin (OVA). IL-4R antibody was injected intravenously before intranasal challenge of OVA with ultrasonic nebulizer. Allergic symptoms, a number of eosinophils in nasal mucosa and serum level of OVA-specific IgE were evaluated.
RESULTS
In IL-4R antibody treated mice, allergic symptom score were decreased (53.5%) than in control mice. The number of eosinophils in nasal mucosa were also reduced (47.4%). However, serum level of OVA-specific IgE were not obviously reduced (14.3%).
CONCLUSION
These results suggested that IL-4R antibody has a potential effect for the treatment of allergic rhinitis in vivo.

Keyword

Interleukin-4 receptor antibody; Allergic rhinitis; Treatment

MeSH Terms

Animals
Eosinophils
Humans
Immunoglobulin E
Injections, Intraperitoneal
Interleukin-4*
Male
Mice
Models, Animal
Nasal Mucosa
Nebulizers and Vaporizers
Ovalbumin
Ovum
Rhinitis
Ultrasonics
Immunoglobulin E
Interleukin-4
Ovalbumin
Full Text Links
  • JR
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr