J Rhinol.  1999 Nov;6(2):91-98.

A Study of the Expression of Cytokines and p53 in Nasal Polyps

Affiliations
  • 1Department of Otolaryngology, College of Medicine, Ewha Womans University, Seoul, Korea.
  • 2Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, Korea.

Abstract

BACKGROUND AND OBJECTIVES: Nasal polyps are a condition of uncertain etiology. Cytokines are thought to play a role in nasal polyps in vitro, but in vivo studies on the patterns of cytokine expression in nasal polyps have been limited. The aim of the present study is to gain a better understanding of the pathophysiology of nasal polyps by defining the patterns of expression of cytokine mRNA and p53 in the nasal mucosa of patients with nasal polyps.
MATERIALS AND METHODS
This objective was supported by performing RT-PCR (reverse transcription-polymerase chain reaction) for IL-2, INF-gamma (T1 cytokine), IL-5, IL-8, IL-10, IL-13 (T2 cytokine), TNF-alpha, TGF-beta1, and p53.
RESULTS
Observation of the nasal polyps indicated significant increases in mRNA for T2 cytokines and p53 over controls. The expressions of IL-10 and IL-13 mRNA in the nasal mucosa of non-allergic patients were stronger than in that of allergic patients.
CONCLUSION
This result suggests that the pathogenesis of nasal polyps is associated with T2 cytokines and p53.

Keyword

Nasal; Polyp; Pathogenesis; Cytokine; p53
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