J Rhinol.
1997 May;4(1):50-56.
Reversibility of Ultrastructural Changes of Cultured Human Nasal Epithelial Cells Induced by Tumor Necrosis Factor-alpha
- Affiliations
-
- 1Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.
Abstract
- Tumor necrosis factor (TNF)-alphacan induce ultrastructural changes in cultured human nasal epithelial cells. The aims of this study are to determine the recovery time from the changes induced by TNF-alphaand observe whether various degrees of changes will result in a complete return to normal status. The recovery of cilia was observed on the third day after cessation of adding TNF-alphaand the normalization of secretory cell area was observed on the fifth day. The morphologic changes induced by TNF-alpha were reversible except with the concentration of 100 ng/ml. The results suggest that the ultrastructural changes induced by TNF-alpha are mostly reversible and that this reversibility corresponds with the in vivo state.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Ultrastructural Changes of Cultured Human Nasal Epithelial Cells by Tumor Necrosis Factor-alpha
- Th2 Responses Elicited by Nasal Epithelial Cells Exposed to House Dust Mite Extract
- Effects of Curcumin and Genistein on Phorbol Ester or Tumor Necrosis Factor-alpha-Induced Mucin Production from Human Airway Epithelial Cells
- Expression of TARC in Nasal Epithelial Cells by IL-4/IL-13 and TNF-alpha in Allergic Rhinitis
- Role of Tumor Necrosis Factor Alpha, Interleukin 8 and Dexamethasone in the FAK Expression by Human Nucleus Pulposus Cells
