Yonsei Med J.  2014 Jul;55(4):912-919. 10.3349/ymj.2014.55.4.912.

Increased Serum Cathepsin K in Patients with Coronary Artery Disease

Affiliations
  • 1Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China. lancui@ybu.edu.cn, chengxw0908@163.com
  • 2Intervention Laboratory, Yanbian University Hospital, Yanji, Jilin P.R., China.
  • 3Central Laboratory, Yanbian University Hospital, Yanji, Jilin P.R., China.
  • 4Department of Anesthesiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
  • 5Department of Physiology and Pathophysiology, Yanbian University Medical College, Yanji, Jilin P.R., China.
  • 6Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • 7Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Korea.

Abstract

PURPOSE
Cathepsin K is a potent collagenase implicated in human and animal atherosclerosis-based vascular remodeling. This study examined the hypothesis that serum CatK is associated with the prevalence of coronary artery disease (CAD).
MATERIALS AND METHODS
Between January 2011 and December 2012, 256 consecutive subjects were enrolled from among patients who underwent coronary angiography and percutaneous coronary intervention treatment. A total of 129 age-matched subjects served as controls.
RESULTS
The subjects' serum cathepsin K and high sensitive C-reactive protein (hs-CRP) and high-density lipoprotein cholesterol were measured. The patients with CAD had significantly higher serum cathepsin K levels compared to the controls (130.8+/-25.5 ng/mL vs. 86.9+/-25.5 ng/mL, p<0.001), and the patients with acute coronary syndrome had significantly higher serum cathepsin K levels compared to those with stable angina pectoris (137.1+/-26.9 ng/mL vs. 102.6+/-12.9 ng/mL, p<0.001). A linear regression analysis showed that overall, the cathepsin K levels were inversely correlated with the high-density lipoprotein levels (r=-0.29, p<0.01) and positively with hs-CRP levels (r=0.32, p<0.01). Multiple logistic regression analyses shows that cathepsin K levels were independent predictors of CAD (odds ratio, 1.76; 95% confidence interval, 1.12 to 1.56; p<0.01).
CONCLUSION
These data indicated that elevated levels of cathepsin K are closely associated with the presence of CAD and that circulating cathepsin K serves a useful biomarker for CAD.

Keyword

Cathepsin K; coronary artery disease; biomarker; high sensitive C-reactive protein; myocardial ischemia

MeSH Terms

Aged
Biological Markers/blood
C-Reactive Protein/metabolism
Cathepsin K/*blood
Coronary Artery Disease/*blood/metabolism
Female
Humans
Male
Middle Aged
Biological Markers
C-Reactive Protein
Cathepsin K

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