Allergy Asthma Immunol Res.  2012 Jan;4(1):52-54. 10.4168/aair.2012.4.1.52.

Meloxicam-Induced Rhabdomyolysis in the Context of an Acute Ross River Viral Infection

• Al Kindi M
• Limaye V
• Hissaria P

• KMID: 2130380
• DOI: http://doi.org/10.4168/aair.2012.4.1.52

Abstract

Acute rhabdomyolysis is a clinical and laboratory syndrome resulting from the breakdown of skeletal muscle, with the release of intracellular contents into the circulatory system, which can cause potentially lethal complications. Here, we present the case of a patient who developed acute rhabdomyolysis after consumption of meloxicam for jaw pain and experienced generalized myalgias in the context of an acute febrile illness with generalized urticaria. Further investigation indicated elevated muscle enzymes and acute renal failure. Serological analysis revealed that the patient was positive for Ross River virus (RRV) IgM. Genetic studies to detect CYP2C9 polymorphisms were negative. Meloxicam was discontinued. He responded to conservative measures within 2 weeks. Oral aspirin challenge was negative, suggesting a drug-specific effect of meloxicam rather than a class effect. Our case indicates a causative role for meloxicam and/or acute RRV in rhabdomyolysis.

Keyword

RRV infection; meloxicam; rhabdomyolysis

MeSH Terms

Acute Kidney Injury
Aspirin
Humans
Immunoglobulin M
Jaw
Muscle, Skeletal
Muscles
Rhabdomyolysis
Rivers
Ross River virus
Thiazines
Thiazoles
Urticaria
Aspirin
Immunoglobulin M
Thiazines
Thiazoles

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