Allergy Asthma Immunol Res.  2012 Jan;4(1):46-48. 10.4168/aair.2012.4.1.46.

A Case of Propofol-Induced Oropharyngeal Angioedema and Bronchospasm

• You BC
• Jang AS
• Han JS
• Cheon HW
• Park JS
• Lee JH
• Park SW
• Kim DJ
• Park CS

• KMID: 2130378
• DOI: http://doi.org/10.4168/aair.2012.4.1.46

Abstract

Propofol (2,6-diisopropylphenol) is an ultrashort-acting sedative agent with sedative and amnestic effects that is used not only for anesthesia but also for sedation during minor outpatient procedures and endoscopic examinations. Rare cases of anaphylaxis following propofol administration have been reported in the medical literature. Documentation of anaphylaxis is often lacking because the cause and effect relationship is often hard to prove. Only a minority of patients get referred for allergy testing to confirm the offending drug. Here we report a 74-year-old woman who had an anaphylactic reaction with severe oropharyngeal edema and bronchospasm for a few minutes after receiving propofol during endoscopic examination. An allergy skin test was positive for both propofol and soybean. Soybean in the intralipid is one component of propofol, and we concluded that this anaphylaxis was caused by soybean.

Keyword

Bronchial spasm; angioedema; anaphylaxis; propofol

MeSH Terms

Aged
Anaphylaxis
Anesthesia
Angioedema
Bronchial Spasm
Edema
Emulsions
Female
Humans
Hypersensitivity
Outpatients
Phospholipids
Propofol
Skin Tests
Soybean Oil
Soybeans
Emulsions
Phospholipids
Propofol
Soybean Oil