J Korean Med Sci.  2015 Feb;30(2):140-144. 10.3346/jkms.2015.30.2.140.

Serum Levels of IL-8 and ICAM-1 as Biomarkers for Progressive Massive Fibrosis in Coal Workers' Pneumoconiosis

• Lee JS
• Shin JH
• Choi BS

• KMID: 2129642
• DOI: http://doi.org/10.3346/jkms.2015.30.2.140

Abstract

Coal workers' pneumoconiosis (CWP) is characterized as a chronic inflammation of the lung associated with activation of macrophages and endothelial cells in the lung. The aim of the present study was to compare the levels of serum interleukin-8 (IL-8), macrophage inflammatory protein-1alpha (MIP-alpha), and intercellular adhesion molecule-1 (ICAM-1) as biomarkers for progressive massive fibrosis (PMF) in 106 subjects (27 non-CWP and 79 CWP patients). The levels of serum IL-8 (P<0.001) and ICAM-1 (P=0.001) of subjects with PMF were higher than those of non-CWP subjects. The IL-8 levels of PMF subjects were also higher than those of simple CWP subjects (P=0.003). Among the subjects without PMF, IL-8 levels in the subjects with International Labour Organization (ILO) category II or III were higher than those in the subjects with ILO category 0 (P=0.006) and with category I (P=0.026). These results suggest that high serum levels of IL-8 and ICAM-1, which are important as neutrophil attractants and adhesion molecules, are associated with PMF.

Keyword

Coal Workers' Pneumoconiosis; Intercellular Adhesion Molecule-1; Interleukin-8; Macrophage Inflammatory Protein-1 Alpha; Progressive Massive Fibrosis

MeSH Terms

Aged
Anthracosis/*blood/pathology
Biological Markers/blood
Chemokine CCL3/*blood
Coal Mining
Humans
Intercellular Adhesion Molecule-1/*blood
Interleukin-8/*blood
Lung/pathology
Male
Middle Aged
Occupational Diseases/blood/pathology
Pulmonary Fibrosis/*blood/pathology
Biological Markers
Chemokine CCL3
Intercellular Adhesion Molecule-1
Interleukin-8

Figure

• 

  Fig. 1 Serum levels of cytokines stratified by ILO category in the subjects without PMF. The mean level of IL-8 in subjects with ILO category II or III was significantly higher than those in subjects with ILO category 0 (P = 0.006) and with ILO category I (P = 0.026). The mean level of MIP-1α in subjects with ILO category II or III was significantly higher than those in subjects with ILO category I (P = 0.031).

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