J Korean Med Sci.  2014 Aug;29(8):1038-1041. 10.3346/jkms.2014.29.8.1038.

Role of Innate Immunity in the Pathogenesis of Type 1 and Type 2 Diabetes

  • 1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. mslee0923@skku.edu


The importance of innate immunity in host defense is becoming clear after discovery of innate immune receptors such as Toll-like receptor or Nod-like receptor. Innate immune system plays an important role in diverse pathological situations such as autoimmune diseases. Role of innate immunity in the pathogenesis of metabolic disorders such as type 2 diabetes, metabolic syndrome or atherosclerosis that has not been previously considered as inflammatory disorders, is also being appreciated. Here, the role of innate immunity in the development of type 1 diabetes, a classical organ-specific autoimmune disease, and type 2 diabetes will be discussed, focusing on the role of specific innate immune receptors involved in these disease processes.


Immunity, Innate; Diabetes Mellitus; Autoimmunity; Lipids; Toll-like Receptor; Nod-like Receptor
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