Ann Lab Med.  2014 Nov;34(6):478-480. 10.3343/alm.2014.34.6.478.

The First Korean Case of Childhood Acute Myeloid Leukemia with Inv(11)(p15q22)/NUP98-DDX10 Rearrangement: A Rare but Recurrent Genetic Abnormality

Affiliations
  • 1Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. sunnyhk@skku.edu
  • 2Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

No abstract available.


MeSH Terms

Asian Continental Ancestry Group/*genetics
Base Sequence
Bone Marrow Cells/metabolism/pathology
Child, Preschool
Chromosome Inversion/*genetics
*Chromosomes, Human, Pair 11
DEAD-box RNA Helicases/*genetics
Humans
Karyotyping
Leukemia, Myeloid, Acute/*diagnosis/genetics
Male
Nuclear Pore Complex Proteins/*genetics
Republic of Korea
DEAD-box RNA Helicases
Nuclear Pore Complex Proteins

Reference

1. Arai Y, Hosoda F, Kobayashi H, Arai K, Hayashi Y, Kamada N, et al. The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10. Blood. 1997; 89:3936–3944. PMID: 9166830.
2. Ikeda T, Ikeda K, Sasaki K, Kawakami K, Takahara J. The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts. Int J Hematol. 1999; 69:160–164. PMID: 10222653.
3. Nebral K, König M, Schmidt HH, Lutz D, Sperr WR, Kalwak K, et al. Screening for NUP98 rearrangements in hematopoietic malignancies by fluorescence in situ hybridization. Haematologica. 2005; 90:746–752. PMID: 15951287.
4. Yamamoto M, Kakihana K, Kurosu T, Murakami N, Miura O. Clonal evolution with inv(11)(p15q22) and NUP98/DDX10 fusion gene in imatinib-resistant chronic myelogenous leukemia. Cancer Genet Cytogenet. 2005; 157:104–108. PMID: 15721630.
5. Morerio C, Acquila M, Rapella A, Tassano E, Rosanda C, Panarello C. Inversion (11)(p15q22) with NUP98-DDX10 fusion gene in pediatric acute myeloid leukemia. Cancer Genet Cytogenet. 2006; 171:122–125. PMID: 17116492.
6. Romana SP, Radford-Weiss I, Ben Abdelali R, Schluth C, Petit A, Dastugue N, et al. NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogénétique Hématologique. Leukemia. 2006; 20:696–706. PMID: 16467868.
7. Gorello P, Nofrini V, Brandimarte L, Pierini V, Crescenzi B, Nozza F, et al. Inv(11)(p15q22)/NUP98-DDX10 fusion and isoforms in a new case of de novo acute myeloid leukemia. Cancer Genet. 2013; 206:92–96. PMID: 23522748.
8. Hollink IH, van den Heuvel-Eibrink MM, Arentsen-Peters ST, Pratcorona M, Abbas S, Kuipers JE, et al. NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern. Blood. 2011; 118:3645–3656. PMID: 21813447.
9. Yassin ER, Abdul-Nabi AM, Takeda A, Yaseen NR. Effects of the NUP98-DDX10 oncogene on primary human CD34+ cells: role of a conserved helicase motif. Leukemia. 2010; 24:1001–1011. PMID: 20339440.
Article
10. Takeda A, Yaseen NR. Nucleoporins and nucleocytoplasmic transport in hematologic malignancies. Semin Cancer Biol. 2014; 27:3–10. PMID: 24657637.
Article
Full Text Links
  • ALM
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2025 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr