J Korean Ophthalmol Soc.
2003 Jul;44(7):1600-1606.
Visual Field Changes in Children with Vigabatrin Treatment
- Affiliations
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- 1Department of Ophthalmology, Soonchunhyang University College of Medicine, Chunan, Korea. cms3445@hanmir.com
- 2Dangjin Woo-ri Eye Clinic, Dangjin, Korea.
Abstract
- PURPOSE
Recently, several reports have documented persistent visual field changes associated with long-term use of Vigabatrin, an antiepileptic drug. Epilepsy is a common disease in children, therefore we investigated perimetric changes in children who were on Vigabatrin treatment. METHODS: Total 36 eyes of 18 patients who had been treated with Vigabatrin were tested with Humphrey Field Analyzer. The visual fields were assessed using central 30-2 threshold test and peripheral 60-4 threshold test. RESULTS: In central 30-2 threshold tests, 13 eyes(40.6%) showed mild visual field constrictions and 4 eyes(12.5%) showed severe visual field constrictions. In peripheral 60-4 threshold tests, 23 eyes(71.8%) showed visual field changes. CONCLUSIONS: Asymptomatic visual field loss may develop in Vigabatrin-treated children. Regular examinations of the visual field is warranted for Vigabatrin-teated children.
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