J Korean Ophthalmol Soc.  1993 Feb;34(2):79-84.

The Morphologic Changes of Epikeratoplasty Lenticule In a Case

Affiliations
  • 1Department of Ophthalmology, School of Medicine Hanyang University, Korea.

Abstract

The patients initially underwent epikeratoplasty for keratoconus but a penetrating kerato plasty was required due to the opacity in the cornea. By using of this specimen, which was obtained by trephination the healing process of the host-Ienticule cornea could be examined by electron microscopy and immunofluorescence method. Epithelial ingrowth over the lenticule was well formed by the regeneration of the basement membrane over the Bowman's membrane. However, the poor attachment of the lenticule over the host corneal stroma made the interface easily separated during the sectioning processes. Electron microscopic study revealed the keratocytes in the lenticule stroma vacuolized with large number of degenerated microorganelles. These results suggest that it may take a long time to complete the wound healing of the host-Ienticule interface despite the epithelial ingrowth onto the lenticule was well formed.

Keyword

Epikeratoplasty; Extracellular matrix; Keratocyte; Lenticule

MeSH Terms

Basement Membrane
Bowman Membrane
Cornea
Corneal Stroma
Epikeratophakia*
Extracellular Matrix
Fluorescent Antibody Technique
Humans
Keratoconus
Microscopy, Electron
Regeneration
Trephining
Wound Healing
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