J Korean Soc Plast Reconstr Surg.  2005 Jan;32(1):19-23.

Comparing Conventional Suture Method Versus Wound Closure Using Tissue Glue(Histoacryl Blue(R)): a Prospective Randomized Clinical Trial

  • 1Institute of Human Tissue Restoration, Yonsei University College of Medicine, Seoul, Korea.
  • 2Department of Plastic & Reconstructive Surgery, Yonsei University College of Medicine, Seoul, Korea. sgm625@yumc.yonsei.ac.kr


Tissue adhesives have gained popularity for quicker and painless closure of lacerations. The use of tissue glue is currently popular for the closure of superficial lacerations, especially in children. Histoacryl Blue(R)(2-N-butylcyanoacrylate) is a topical wound closure that precludes the need for foreign bodies to close wounds. The purpose of this study was to compare the applications of Histoacryl Blue(R)(HAB) and conventional suture, regarding cosmetic outcome. To compare the short term and long term results of various repair methods, we designed the prospective, randomized, blind study. Patients with laceration undergoing repair were randomly allocated to conventional suture, subcutaneous suture plus HAB, and HAB only groups. The exclusion criterions were large wound that require large tension for repair or avulsion wound. An independent, blinded observer assessed cosmetic result at 7-10 days after repair and 3-9 months postoperatively. Physician's satisfaction with wound appearance was recorded on 100 mm Visual Analogue Scale(VAS)(0=worst, 100=best). The difference in VAS score between conventional suture method and subcutaneous suture plus HAB methods were not significant. Tissue glue being easy to use with no complications and still resulting in equivalent cosmetic outcomes has several benefits. Especially in the case of children, the wound closure with Histoacryl Blue(R) could be a good alternative for repair of laceration in emergency room.


Histoacryl Blue(R); Conventional suture; VAS score; Prospective randomized blinded study
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