Korean J Blood Transfus.  2012 Aug;23(2):173-179.

Two Cases of Anti-Jka Whose Reactivity Was Disappeared after Enzyme Treatment

Affiliations
  • 1Department of Laboratory Medicine, Chonbuk National University Medical School, Jeonju, Korea. choyg@jbnu.ac.kr
  • 2Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.
  • 3Chonbuk National University Hospital Culture Collection for Pathogens, Jeonju, Korea.

Abstract

We report on two cases of anti-Jka, whose reactivity disappeared on an antibody identification test using enzyme-treated red cells. One of two patients was a 72-year-old female with cirrhosis of the liver and colon cancer, and the other was a 55-year-old female with known MDS and incomplete Behcet's disease. Results of an antibody identification test using a LISS/Coombs gel card (DiaMed AG) showed negative to one positive with red cells having the Jka antigen; however, all reactions using the enzyme-treated cells showed negative results, which was unexpected. The patients' RBC phenotype was Jk(a-b+). We obtained positive results in reactions of enzyme-treated Jka+ cells and EDTA using a patient's serum and proved that the cause of the negative reaction might be complement-related.

Keyword

Anti-Jka; Enzyme; EDTA

MeSH Terms

Aged
Colonic Neoplasms
Edetic Acid
Female
Fibrosis
Humans
Liver
Middle Aged
Phenotype
Edetic Acid
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