Korean J Urol.  1992 Oct;33(5):806-811.

The role of serum prostate specific antigen in prostatic cancer and benign prostatic hyperplasia

  • 1Department of Urology, Asan Medical Center, University of Ulsan, Seoul, Korea.


Serum prostate specific antigen was measured in 26 patients with prostatic cancer, 83 patients with benign prostatic hyperplasia. 12 healthy men without prostate disease and 5 females as normal control using immunoradiometric assay. Reference intervals established for healthy men and women were 0.1-2.5 ng/ml and the proportion of PSA values exceeding the reference interval was 96.2% ror patients with prostate cancer and 62% for men with benign prostatic hyperplasia. Acid phosphatase (AP) was elevated above normal level (up to 4U/d1) in 9 of 26 (34.6%) prostatic cancer patients and in 2 of 83 (2.4%) benign prostatic hyperplasia patients. In prostatic carcinoma the sensitivity and specificity were 96.2% and 50.0% for PSA values of greater than 4 ng/ml and they were 88.5% and 86.0% for PSA concentrations of greater than 20 ng/ml, respectively. Serum PSA is considered to be a useful diagnostic tool for prostatic cancer if we determine the positive predictive value for serum PSA concentration above 20 ng /ml.


prostate specific antigen; prostatic cancer; benign prostatic hyperplasia

MeSH Terms

Acid Phosphatase
Immunoradiometric Assay
Prostate-Specific Antigen*
Prostatic Hyperplasia*
Prostatic Neoplasms*
Sensitivity and Specificity
Acid Phosphatase
Prostate-Specific Antigen
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