Effects of Prostaglandins and Oxytocin on the Contractility of Isolated Detrusor Muscle strips in Rabbit

Lee, Jong Gun

Abstract

The effects of prostaglandins and oxytocin on the contractility of detrusor muscle was investigated in the isolated detrusor muscle strips of rabbit. Contractility was measured on the Physiograph with force transducer by means of Magnus method in the Locke`s solution. The results were summarized as follows. 1. Prostaglandin E, and F2a enhanced the contractility of detrusor muscle and that was more potent in prostaglandin E2. 2. Indomethacin reduced the contractility of detrusor muscle. 3. The effects of prostaglandin E2 and F2a on the contractility of detrusor muscle was not blocked by indomethacin and atropine. 4. Oxytocin enhanced the contractility of detrusor muscle significantly and the patterns of enhancement was similar that of the prostaglandins. 5. Progesterone reduced the contractility but the estrogen didn`t affect the contractility of detrusor muscle. 6. The effect of oxytocin on the contractility of detrusor muscle was not affected by progesterone estrogen and also was not blocked by indomethacin and atropine. From the above results, it was suggested that oxytocin enhance not only the contractility of detrusor muscle but also its action was similar that of prostaglandins.