Lab Anim Res.  2010 Dec;26(4):429-432. 10.5625/lar.2010.26.4.429.

Rectal Prolapse Associated with Recurrent Diarrhea in a Laboratory Cynomolgus Monkey (Macaca fascicularis)

  • 1The National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang, Korea.
  • 2Functional Genomics, University of Science and Technology (UST), Daejeon, Korea.
  • 3Department of Veterinary Pathology, College of Veterinary Medicine, Chungnam National University, Daejeon, Korea.


Rectal prolapse is a protrusion of one or more layers of the rectum through the anus. A 5-year-old laboratory cynomolgus monkey who had suffered from recurrent diarrhea died after surgical resection of a prolapsed rectum. On examination, the prolapsed rectum was a cylinder-shaped tissue whose surface was moist and dark red with a small amount of hemorrhage. Histologically, the rectum was characterized by a segmental to diffuse cellular infiltration in the submucosa and muscle layers. Inflammation in the rectum resulted in irritation of the myenteric plexus, which could cause hypermotility of the intestines, leading to chronic diarrhea. Rectal prolapse would result in economical loss or death of laboratory animals. However, rectal prolapse in the laboratory monkey could be easily overlooked because diarrhea or other symptoms resulting from rectal prolapse could be sometimes misunderstood as a primary problem. Therefore, researchers should suspect rectal prolapse if intestinal symptoms in the laboratory monkey are untreatable.


Rectal prolapse; laboratory cynomolgus monkey; recurrent diarrhea

MeSH Terms

Anal Canal
Animals, Laboratory
Macaca fascicularis
Myenteric Plexus
Preschool Child
Rectal Prolapse


  • Figure 1. Rectal prolapse of the laboratory cynomolgus monkey. Cylinder-shaped prolapsed rectum was protruded through the anus. The surface of the prolapsed rectum is moist and dark red with a small amount of hemorrhage.

  • Figure 2. Histological findings of the prolapsed rectum of the laboratory cynomolgus monkey. (A) The rectum is characterized by a segmental to diffuse cellular infiltration in the submucosa and muscle layers. H&E stain (×40). (B) In the submucosa, the lymphatic vessels were markedly dilated and contain a number of neutrophils admixed with a few number of monocytes and lymphocyte and abundant amount of fibrin (×400). (C) Numerous neutrophils with a few lymphocyte in the submucosa penetrated into muscle layers (×200).



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