J Korean Ophthalmol Soc.  2007 Jun;48(6):789-798.

Photodynamic Therapy for Choroidal Neovascularization Secondary to Age-Related Macular Degeneration

Affiliations
  • 1Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea. chungh@snu.ac.kr
  • 2Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 3Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University, College of Medicine, Seoul, Korea.
  • 4Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
  • 5Department of Ophthalmology, KyungHee University College of Medicine, Seoul, Korea.
  • 6Department of Ophthalmology, Kyungpook National University, College of Medicine, Daegu, Korea.
  • 7Department of Ophthalmology, College of Medicine, Inje University, Pusan, Korea.
  • 8Department of Ophthalmology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 9Department of Ophthalmology, Konkuk University College of Medicine, Seoul, Korea.
  • 10Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 11Department of Ophthalmology, Chonnam National University Medical School & Hospital, Gwangju, Korea.
  • 12Department of Ophthalmology, College of Medicine, Pusan National University, Pusan, Korea.
  • 13Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
  • 14Department of Ophthalmology, Konyang University, Kim's Eye Hospital, Seoul, Korea.
  • 15Department of Ophthalmology, Ewha Womans University College of Medicine, Seoul, Korea.
  • 16Department of Ophthalmology, The Chosun University Medical College, Gwangju, Korea.

Abstract

PURPOSE: To investigate the effects of repeated photodynamic therapy (PDT) for subfoveal choroidal neovascularization secondary to age-related macular degeneration (AMD) in Korean patients.
METHODS
Clinical data of patients who were treated with repeated (3 times or more) PDT for subfoveal choroidal neovascularization secondary to AMD and followed up for more than 6 months were collected from 17 hospitals around the country. Visual outcomes at 12 and 24 months, follow-up were compared between subtypes of choroidal neovascularization. The factors related to final visual prognosis and PDT-related adverse effects were evaluated.
RESULTS
244 patients (244 eyes) were recruited (male: 60%, age: 67.7+/-9.1 years). The portion of patients with predominantly classic, minimally classic, and occult without classic choroidal neovascularization was 57%, 13%, and 24%, respectively and that of patients with visual improvements or less than moderate visual loss at 24 months follow-up were 28%, 38%, 30% and 47%, 56%, and 65%, respectively. Baseline visual acuity and age were significantly related to the final visual prognosis (p<0.05). PDT-related adverse events developed in 15 (6.1%) patients, but most were mild and transient.
CONCLUSIONS
Repeated PDT for subfoveal choroidal neovascularization secondary to AMD has effects comparable to those of previous prospective, controlled trials without any significant safety concerns in Korea.

Keyword

Age-related macular degeneration (AMD); Choroidal neovascularization (CNV); Photodynamic therapy (PDT)

MeSH Terms

Choroid*
Choroidal Neovascularization*
Follow-Up Studies
Humans
Korea
Macular Degeneration*
Photochemotherapy*
Prognosis
Visual Acuity
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