J Korean Ophthalmol Soc.  1993 Apr;34(4):299-303.

The Effect of Vitreous on Proliferation of Retinal Pigment Epithelial CelIs

• Lee SC
• Kwon OW

Abstract

Several studies have indicated that retinal pigment epithelial(RPE) cells migrate from their normal location into the vitreous cavity where they then undergo proliferation and membrane formation in proliferative vitreoretinopathy(PVR). Little attention has been given to the role of vitreous on cellular proliferation. Our study is to determine the effect of vitreous on RPE cell proliferation and to examine the morphology of cultured RPE cells on vitreous explants. The vitreous from pigmented rabbit was extracted and added to the cultured media RPE cells proliferated rapidly along the margin of the vitreous as fibrocyte like cells and were less invasive into the virtrous gel. Liquified vitreous with media stimulated the proliferation of RPE cells, but vitreous alone showed the decrease of inoculated RPE cells.

Keyword

RPE cells; Cell proliferation; Vitreous; Proliferative vitreoretinopathy

MeSH Terms

Cell Proliferation
Membranes
Retinaldehyde*
Vitreoretinopathy, Proliferative
Retinaldehyde