J Korean Orthop Assoc.  2004 Feb;39(1):88-93.

Immunoreactivity of Somatostatin Receptor Subtype 2 in Dorsal Root Ganglia in the Rat

Affiliations
  • 1Department of Orthopaedic Surgery, Kangnam Sacred Heart Hospital, Hallym University School of Medicine, Seoul, Korea. rohgc@yahoo.co.kr
  • 2Department of Anatomy, College of Medicine, Hallym University, Chunchon, Korea.

Abstract

PURPOSE
Somatostatin has been suggested to play a role in the transmission of neurotransmitters and in the modulation of pain. Of the different subtypes of somatostatin receptors 2, sstr2A and sstr2B are important in the modulation and transmission of pain. The present study was carried out to investigate sstr2 immunoreactivity in rat. MATERIALS AND METHODS: Dorsal root ganglia (DRG) cells at the L4-L6 levels of the spinal cord of 10 rats (Sprague-Dawley, 200-250 g) were examined for sstr2 by immunohistochemistry. RESULTS: In the control group, sstr2A immunoreactivity was strongly positive in the dense network within laminae I and II of the dorsal horn at spinal levels (L4-L6). In contrast to sstr2A, sstr2B immunoreactivity was observed throughout laminae III-VI. In the DRG, sstr2A and sstr2B immunoreactivities were mainly found in medium-sized neurons. CONCLUSIONS: The distribution of sstr2A immunoreactive cells among sstr2 in the dorsal root ganglia (L4-6) resembles that of somatostatin. Incontrast to sstr2A, sstr2B immunoreactivity showed a different distribution. The presence of sstr2A at laminae I and II, and sstr2B at laminae III-VI of the dorsal horn may modulate sensory functions at these different regions of the spinal cord. Considering different actions according to the receptors of the neurotransmitter, the functions of the isoforms of sstr2 appear variable in terms of modulating and transmitting pain.

Keyword

Neurogenic pain; Somatostatin; Somatostatin receptors 2 (sstr2); Immunohistochemistry

MeSH Terms

Animals
Diagnosis-Related Groups
Ganglia, Spinal*
Horns
Immunohistochemistry
Neurons
Neurotransmitter Agents
Protein Isoforms
Rats*
Receptors, Somatostatin*
Sensation
Somatostatin*
Spinal Cord
Spinal Nerve Roots*
Neurotransmitter Agents
Protein Isoforms
Receptors, Somatostatin
Somatostatin
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