J Korean Pediatr Soc.  1993 Aug;36(8):1067-1072.

Intermittent central nervous system irradiation and intrathecal chemotherapy for recurrent central nervous system leukemia in children

• Bang JH
• Chung NG
• Choi WG
• Kim HK
• Lee KS
• Yang MK

Abstract

Between 1986 and 1990, four children with recurrent CNS leukemia who had previous CNS prophylaxis therapy were treated with intermittent central nervous system irradiation and intrathecal chemotherapy (IIIC). There was no isolated CNS recurrence. One patient died form bone marrow relapse. Three patients are alive without evidence of disease for 3E3/12 year to 3E6/12 year after the diagnosis of recurrence of CNS leukemia. This experience suggests that IIIC may be an effective treatment for preventing the recurrence of CNS leukemia without any serious side effects.

Keyword

Acute lymphocytic leukemia; CNS inrradiation; Intrathecal chemotherapy

MeSH Terms

Bone Marrow
Central Nervous System*
Child*
Diagnosis
Drug Therapy*
Humans
Leukemia*
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Recurrence