J Korean Radiol Soc.  2003 Jan;48(1):7-11. 10.3348/jkrs.2003.48.1.7.

Evaluation of the Release Behavior of the Dexamethasone Embedded in Polycarbonate Polyurethane Membranes: An In Vitro Study

Affiliations
  • 1Department of Diagnostic Radiology, Chosun University Hospital, College of Medicine, Korea. gangsg@mail.chosun.ac.kr
  • 2Department of Biomedical Engineering, Seoul Health College, Korea.
  • 3Department of Internal Medicine, Inha University, College of Medicine, Korea.
  • 4Department of Biomedical Engineering, Korea University, College of Medicine, Korea.
  • 5Department of OEM, Chosun University Hospital, College of Medicine, Korea.
  • 6Department of Diagnostic Radiology, Ulsan University, College of Medicine, Korea.

Abstract

PURPOSE: To evaluate the release behavior of dexamethasone embedded in a polycarbonate polyurethane membrane.
MATERIALS AND METHODS
Both water-soluble and water-insoluble dexamethasone were tested, and the release behavior of five water-insoluble dexamethasone films of different thickness (78 to 211 micrometer) was also evaluated. The amount of Dexamethasone used was 10% of the total weight of the polyurethane film mass. Each film was placed in a centrifuge tube containing 25 ml of 0.1-M neutral phosphate buffer, and the tubes were placed in a shaking incubator to quantify the amount of drug released into the buffer, absorption spectroscopy (lambda max=242 nm) was employed.
RESULTS
In the test involving water-soluble dexamethasone, 60% of the drug was released during the first two hours of the study. Films containing water-insoluble Dexamethasone, on the other hand, released 40%, 60% and 75% of the dexamethasone in one, three and seven days, respectively. Both types of film maintained low-dose drug release for 28 days. When release behavior was compared between water-insoluble films of different thickness, thicker film showed less initial burst and more sustained release.
CONCLUSION
Dexamethasone release behavior varies according to drug solubility and membrane thickness, and may thus be conrolled.

Keyword

Drugs, side effects; Stents and prostheses; Experimental study

MeSH Terms

Absorption
Dexamethasone*
Hand
Incubators
Membranes*
Polyurethanes*
Solubility
Spectrum Analysis
Dexamethasone
Polyurethanes
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