J Korean Surg Soc.  2007 Jan;72(1):32-37.

Locally Administered Ketorolac and Bupivacaine for Control of Postoperative Pain in LAG for Gastric Cancer: Prospective Randomized Double Blind Study

• Kim MC
• Kang TY
• Park KJ
• Kim SH
• Jung GJ
• Lee SC
• Kim HY

Abstract

PURPOSE: The method of locally administered ketorolac and bupivacaine with epinephrine in LAG patients was examined for the control of postoperative pain.
METHODS
Fifty-one patients who had undergone LAG for gastric cancer from Jan. 2005 and Aug. 2005 were enrolled in this study. All the patients were administered a fentanyl patch (25 microgram/hr) on the upper back 2 hours before the entry into the OR. Upon the completion of LAG, the patients were randomly selected for a local injection of Ketolorac and bupivacaine. Ketolorac (30 mg, 1 cc) plus 0.5% bupivacaine with 1 : 100,000 epinephrine (9 cc) was injected in the peritoneum and subcutaneous tissue of the mini-laparotomy wound in the study group, and normal saline (10 cc) was injected into the control group. The postoperative pain scores were assessed at 6 hr, day 1, day 2 and day 5 using a Verbal Numerical Rating Scale by a Wound Ostomy Continence Nurse. Meperidine (25 mg iv.) was used for additional analgesia.
RESULTS
The frequency of additional analgesic requirement was significantly lower in the study group and the pain score was significantly lower at 6 hr postoperatively than in the control group.
CONCLUSION
Locally administered ketorolac and bupivacaine with epinephrine is a simple and cost-effective technique for alleviating postoperative pain in LAG patients with gastric cancer.

Keyword

LAG; Pain control; Local anesthesia

MeSH Terms

Analgesia
Anesthesia, Local
Bupivacaine*
Double-Blind Method*
Epinephrine
Fentanyl
Humans
Ketorolac*
Meperidine
Ostomy
Pain, Postoperative*
Peritoneum
Prospective Studies*
Stomach Neoplasms*
Subcutaneous Tissue
Wounds and Injuries
Bupivacaine
Epinephrine
Fentanyl
Ketorolac
Meperidine