J Korean Surg Soc.  2006 Sep;71(3):222-225.

SMV Thrombosis on Taking Oral Contraceptive with Protein C and Protein S Deficiency

• Yeo MS
• Kwon YS
• Choi SH
• Kim KH
• Byun CG
• Koh YT
• Suh DY
• Lee HJ

Abstract

Mesenteric venous thrombosis (MVT) is uncommon, but it is often aggravated to a lethal form of intestinal ischemia. Multiple risk factors are associated with mesenteric venous thrombosis, including hypercoagulable or inflammatory states, previous abdominal surgery, abdominal trauma, portal hypertension and oral contraceptives. The use of estrogen-containing oral contraceptives accounts for 4% to 5% of all the cases of MVT. Oral contraceptives have been reported to decrease antithrombin III, increase the levels of prothrombin complex factor and factor VIII, and to inhibit the fibrinolytic system. We describe here a case of 42-year-old woman who had taken oral contraceptives for 7 years and she was diagnosed to have Protein C and Protein S deficiency, and superior mesenteric venous (SMV) and portal vein thrombosis. She underwent segmental resection of the small bowel. She was later discharged without suffering with short bowel syndrome or any other complications.

Keyword

Mesenteric venous thrombosis; Hypercoagulable; Oral contraceptive

MeSH Terms

Adult
Antithrombin III
Contraceptives, Oral
Factor VIII
Female
Humans
Hypertension, Portal
Ischemia
Protein C*
Protein S Deficiency*
Protein S*
Prothrombin
Risk Factors
Short Bowel Syndrome
Thrombosis*
Venous Thrombosis
Antithrombin III
Contraceptives, Oral
Factor VIII
Protein C
Protein S
Prothrombin