Korean Circ J.  1996 Feb;26(1):130-137. 10.4070/kcj.1996.26.1.130.

Thrombolytic Therapy in the 8 Cases of left Ventricular Thrombus after Transmural Anterior Myocardial Infarction

• Lee JL
• Park JW
• Shin DG
• Kim YJ
• Shim BS

• KMID: 2093572
• DOI: http://doi.org/10.4070/kcj.1996.26.1.130

Abstract

The 8 cases of left ventricular thrombus detected by the 2 D echocardiography or left ventriculography, after acute transmural anterior myocardial infarction were effectively lysed by the thrombolytic agents and heparin therapy. The thrombolytic agents were either urokinase or tissue plasminogen activator. Urokinase was infused intravenously at a dose of 1.0 million unit for three days. And tissue plasminogen activator was infused at a dose of 100mg for a day. In all cases, the thrombi were completely lysed. At follow up, no recurrence of left ventricular thrombus was found. We have experienced 2 cases of peripheral embolization in which, left ventricular thrombi were protruding nonmobile type. The one was the embolic cerebral infarction, the other was transient hoarseness and paresthesia on the left foot, which may be transient ischemic attack. These results show that left ventricular thrombi can be treated by intravenous thrombolytic agents without life-threatening complication. However, for the better establishment of the risk and benefit of therapy further investigation is needed.

Keyword

Left ventricular thrombus; Acute myocardial infarction; Thrombolytic therapy

MeSH Terms

Cerebral Infarction
Echocardiography
Fibrinolytic Agents
Follow-Up Studies
Foot
Heparin
Hoarseness
Ischemic Attack, Transient
Myocardial Infarction*
Paresthesia
Recurrence
Thrombolytic Therapy*
Thrombosis*
Tissue Plasminogen Activator
Urokinase-Type Plasminogen Activator
Fibrinolytic Agents
Heparin
Tissue Plasminogen Activator
Urokinase-Type Plasminogen Activator