Korean J Anat.  2009 Jun;42(2):131-138.

Expression and Distribution of BDNF (Brain Derived Neurotrophic Factor) in the Rat Hypothalamus

Affiliations
  • 1Department of Anatomy, College of Medicine, Dankook University, Cheonan, Korea. anat104@dku.edu
  • 2Department of Rehabilitation Medicine, College of Medicine, Dankook University, Cheonan, Korea.

Abstract

BDNF belongs to the neurotrophin family and important molecular mediator of functional and structural plasticity. The highest levels of BDNF are found in the hippocampus and hypothalamus of the adult rat. Hypothalamus is important because of its high degree of plasticity, but little is known about distribution of BDNF in hypothalamic nuclei. Therefore, it is necessary to study distribution and expression pattern of BDNF in each hypothalamic nuclei to understand changes of BDNF through various neural damages including spinal cord injury. Through this experiment, we found specific BDNF expression pattern in some regions of hypothalamus and the results are as follows. 1) BDNF expressions were found in median eminence, arcuate nucleus, supraoptic nucleus, and periventricular nucleus of rat hypothalamus. 2) BDNF immunoreactive cells and nerve fibers were of various shapes and sizes. 3) Glial cells also express BDNF in certain hypothalamic nuclei. These results seem to be useful for future investigations of neurochemical changes in the hypothalamus induced by various neural trauma or degenerative changes

Keyword

Hypothalamus; Double immunofluorescent staining; Neurotrophic factor; BDNF (brain derived neurotrophic factor)

MeSH Terms

Adult
Animals
Arcuate Nucleus
Brain-Derived Neurotrophic Factor
Hippocampus
Humans
Hypothalamus
Median Eminence
Nerve Fibers
Neuroglia
Plastics
Rats
Spinal Cord Injuries
Supraoptic Nucleus
Brain-Derived Neurotrophic Factor
Plastics
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