Korean J Asthma Allergy Clin Immunol.
2011 Mar;31(1):59-62.
A Case of Carbamazepine-induced DRESS Syndrome
Abstract
- DRESS (Drug rash with eosinophilia and systemic symptoms) syndrome is a rare and potentially life-threatening drug reaction, which has been associated with aromatic anticonvulsants such as phenytoin, carbamazepine and phenobarbital. It is characterized by hematologic abnormalities, especially eosinophilia and mononucleosis-like atypical lymphocytosis, skin rash, fever, lymph node enlargement and single or multiple organ involvement, which starts within 8 weeks of the initiation of therapy. Despite these characteristic findings, generally clinicians have difficulty finding out culprit drugs. Herein, we report a case of carbamazepine-induced DRESS syndrome which developed erythematous skin eruptions 8 weeks after carbamazepine therapy.
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