Korean J Dermatol.  2003 Nov;41(11):1541-1543.

A Case of Type IIa Hyperlipoproteinemia and Coronary Artery Disease Associated with Xanthoma Tendinosum

• Lee CW
• Sim SJ
• Song KH
• Kim KH

Abstract

We report a case of type IIa hyperlipoproteinemia with xanthoma tendinosum associated with coronary artery disease in a 51 year-old male. Multiple hard nodules appeared firstly on both achilles tendon area 30 years ago and the lesions gradually spread to the dorsa of hands and feet. On past history, he had been diagnosed as unstable angina with atherosclerosis of three vessels in coronary arteries, 2 years ago. His family history revealed nothing contributory. Serum lipid profile including lipoprotein electrophoresis showed an increase in total cholesterol and LDL-cholesterol with increased beta-lipoprotein fraction, which suggested type IIa hyperlipoproteinemia. Histopathologic finding of a nodule from the dorsum of right hand showed many foamy histiocytes and cholesterol clefts in the dermis. Most of the xanthoma cells were mononuclear, but many Touton type giant cells were seen also. He died suddenly of heart failure with unstable angina.

Keyword

Hyperlipoproteinemia; Xanthoma tendinosum; Atherosclerosis

MeSH Terms

Achilles Tendon
Angina, Unstable
Atherosclerosis
Cholesterol
Coronary Artery Disease*
Coronary Vessels*
Dermis
Electrophoresis
Foot
Giant Cells
Hand
Heart Failure
Histiocytes
Humans
Hyperlipoproteinemia Type II*
Hyperlipoproteinemias
Lipoproteins
Male
Middle Aged
Xanthomatosis*
Cholesterol
Lipoproteins