Korean J Dermatol.  2003 Nov;41(11):1517-1520.

A Case of Multiple Myeloma First Presenting as Cutaneous Plasmacytoma

• Kang JD
• Kim SJ
• Youn NH
• Park SD

Abstract

Cutaneous extramedullary plasmacytomas are rare in patients with multiple myeloma, they usually indicate a large tumor cell burden and fatal outcome. A 55-year-old man presented with multiple cutaneous tender nodules or masses on whole body. A biopsy specimen of cutaneous nodule showed dermal infiltration by well differentiated plasma cells. Many atypical and immature plasma cells were found in a bone marrow smear and biopsy. A serum protein electrophoresis revealed elevated quantities of Ig G-globulin with type lambda light chain. The patient was treated with VAD(vincristine, adriamycin, dexamethasone) chemotherapy, but died with pulmonary edema and acute respiratory distress syndrome. We report a fatal case of multiple myeloma first presenting as multiple extramedullary cutaneous plasmacytomas.

Keyword

Cutaneous extramedullary plasmacytoma; Multiple myeloma

MeSH Terms

Biopsy
Bone Marrow
Doxorubicin
Drug Therapy
Electrophoresis
Fatal Outcome
Humans
Middle Aged
Multiple Myeloma*
Plasma Cells
Plasmacytoma*
Pulmonary Edema
Respiratory Distress Syndrome, Adult
Doxorubicin