Korean J Dermatol.
2000 Feb;38(2):245-248.
A Case of Necrobiosis Lipoidica Diabeticorum with Koebner Phenomenon
- Affiliations
-
- 1Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.
- 2Department of Pathology, Hanyang University College of Medicine, Seoul, Korea.
Abstract
- The isomorphic response of Koebner is a well-known phenomenon commonly associated with psoriasis, but it has been also described in conjuction with a host of other disorders. However it has seldom been associated with necrobiosis lipoidica diabeticorum, a rare skin manifestation of diabetes mellicuts. In this report, we describe a 59-year-old woman who developed necrobiosis lipoidica diabeticorum on the left shin where a mosquito had bitten her 2 months ago. Four months ago, she was diagnosed as necrobiosis lipoidica diabeticorum on the right forearm and shin by biopsy and the lesions were improved with corticosteroids intralesional injection. The lesions were asymptomatic and had grown slowly. Histopathological findings showed a large palisading granulomas composed of histiocytes, epithelioid cells and areas of necrobiosis of collagen with multinucleated giant cells. Van Gieson stain showed decreased and fragmented elastic fibers and there were no deposits of mucin in the necrobiotic areas. The lesions were improved with triamcinolone acetonide intralesional injection and there was no recurrence during 4 months.
MeSH Terms
-
Adrenal Cortex Hormones
Biopsy
Collagen
Culicidae
Elastic Tissue
Epithelioid Cells
Female
Forearm
Giant Cells
Granuloma
Histiocytes
Humans
Injections, Intralesional
Middle Aged
Mucins
Necrobiosis Lipoidica*
Necrobiotic Disorders*
Psoriasis
Recurrence
Skin Manifestations
Triamcinolone Acetonide
Adrenal Cortex Hormones
Collagen
Mucins
Triamcinolone Acetonide
