Korean J Dermatol.  2000 Jan;38(1):51-58.

Immunohistochemical Study of Trichoblastoma

Affiliations
  • 1Department of Dermatology, College of Medicine, University of Ulsan, Seoul, Korea.

Abstract

BACKGROUND: Trichoblastoma is a rare benign neoplasm. Trichoblastoma and basal cell carcinoma are generally held to be distinctive epithelial neoplasms with some overlapping features. There are only a few reports on immunohistochemical studies of these neoplasms.
OBJECTIVE
The purpose of this study was to investigate the immunohistochemical staining patterns of trichoblastoma and compare them with those of basal cell carcinoma.
METHODS
We performed immunoperoxidase staining using 11 different monoclonal antibodies on formalin fixed, paraffin-embedded sections of 4 cases of trichoblastoma and 4 cases of basal cell carcinoma.
RESULTS
The antibodies 34betaE12 (against CK 1, 5, 10, 11), MNF116 (against CK 5, 6, 8,17, and probably CK19), LL002 (against CK 14) was positive in the tumor cells of epithelial cords and cystic structures in all cases of trichoblastoma and basal cell carcinoma. SY20 (against involucrine) was detected in the inner layers of keratinous cysts in all cases of tichoblastoma and basal cell carcinoma. Ks20.8 (against CK 20) was detected in one case of trichoblastoma and OV/TL12/30 (against CK7) was detected in one case of basal cell carcinoma.
CONCLUSION
Trichoblastoma and basal cell carcinoma reveal similar patterns of cytokeratin expression in paraffin sections. We can speculate that the trichoblastoma differentiate mainly into isthmus portion of outer root sheath beneath the infundibulum.

Keyword

Trichoblastoma; Immunohistochemical study
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