Korean J Dermatol.  1994 Nov;32(6):1026-1034.

Effect of Several Solvents on Irritant Dermatitis Measured by Non - invasive Techniques

Abstract

BACKGROUND: Solvents play an immense role in the industria sector. Irritant dermatitis which is more common than allergic contact dermatitis can be caused by solvents.
OBJECTIVE
Our purpose was to compare the skin irritancy of several solvents using human and guinea pig skin models.
METHODS
The skin responses to short contact with etharol, acetone, dimethylsulfoxide (DMSO) and xylene were measured by visual scoring of erythm, transepidermal water loss and laser doppler flowmetry.
RESULTS
The results are summarized as follows . 1. Guinea pig and human skin responses to normal saline, ethanol, and acetone were nearly negligible. 2. Guinea pig skin responses to 99.9% DMSO under occlusion for 0.5 min were assessed by visual scoring system, TEWL, and LDF. They are measured 3+0.(0,1+21.70, 45+12.70 at 5 min after removal of 99.9% DMSQ, and 0.83+0.41, 10.5+3.83, 36+4.0, to 120 min after removal. 3. Guinea pig skin responses to 97% xylene under occlusion for 5 nin were assessed by visual scoring system, TEWL and LDF. They are measured 3+0.00, 1. 5.82, 77+11.7 at 5 min after removal of 97% xylene, and 1.83+0.75, 5.5+3.21, 39.17+11.53 at l2 min after removal. 4. Human skin responses to 75% DMSO under occlusion for 1 min were assessed by visual scoring system, TEWL and LDF. They are measured 2,5+0.5, 63+25.8, 51+13.7 at 5 min after removal of 75% DMSO, and 0.17+0.41, 14.67+15.87, 21.17-8. 1 at 120 min after removal. 5. Human skin responses to 97% xylene under occlusion for 12 min were assessed by visual scoring system, TEWL and LDF. They are measured 2.7+0.52+4.22, 76+14.30 at 5 min after removal of 97% xylene, and 0+0, 2.5+0.55, 3.17+0.98, 120 emOVBI.
CONCLUSION
Short contact vrith DMSO and xylene cause visib erythema and an increase in TEWL and cutaneous blood flow. The reaction patterns in hurr an and guinea pig skin models were similar.

Keyword

Lichenoid Drug; Eruption; Lichen Planus; Histopathologic Diat ferentiation

MeSH Terms

Acetone
Animals
Dermatitis, Allergic Contact
Dermatitis, Irritant*
Dimethyl Sulfoxide
Erythema
Ethanol
Guinea Pigs
Humans
Laser-Doppler Flowmetry
Lichen Planus
Skin
Solvents*
Xylenes
Acetone
Dimethyl Sulfoxide
Ethanol
Solvents
Xylenes
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