Korean J Gastroenterol.  1999 Mar;33(3):321-330.

The Role of Helicobacter pylori In fection and cagA Expression in Gastric Carcinogenesis

Abstract

BACKGROUND/AIMS: The aim of this study was to study the role of Helicobacter pylori infection and cagA expression in gastric carcinogenesis.
METHODS
One hundred forty six patients were divided into three groups. Case group included 50 patients with gastric adenocarcinoma. Control group 1 included 38 patients with nongastric cancer, and control group 2 included 58 patients with nonulcer dyspepsia Biopsy specimens were evaluated to detect the presence of Helicobacter pylori by histology, rapid urease test and reverse transcription-polymerase chain reaction (RT-PCR) using primers specific for 16S rRNA and cagA mRNA of Helicobacter pylori.
RESULTS
The expression rates of 16S rRNA and cagA mRNA of Helicobacter pylori in patients with gastric carcinoma were 74% and 51%, respecti vely. Although 90% of patients with gastric carcinoma had Helicobacter pylori infection, the signifi cant association between Helicobacter pylori infection and gastric carcinoma was not observed. There was no significant association between cagA expression and gastric carcinoma.
CONCLUSIONS
Helico bacter pylori infection and cagA expression were not associated with the risk of gastric carcinoma.

Keyword

Helicobacter pylori; Gastric carcinoma; cagA

MeSH Terms

Adenocarcinoma
Biopsy
Carcinogenesis*
Dyspepsia
Helicobacter pylori*
Helicobacter*
Humans
RNA, Messenger
Urease
RNA, Messenger
Urease
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