Korean J Gastroenterol.  1998 Jun;31(6):846-851.

Two Cases of Autoimmune Cholangiopathy

• Moon YM
• Park CI
• Lee CK
• Choe BH
• Park YN
• Han KH
• Park YB
• Lee SK
• Whang YW

Abstract

We describe two patients showing features of primary biliary cirrhosis but negative antimitochondrial antibody. Botn were females. Serum biochemical study showed increase in alkaline phosphatase and gamma glutamyl transpeptidase levels. Markers of hepatitis B and C virus were absent. In both patients, serum anti-mitochondrial antibodies were not detected on immunofluorescence study. Both had high titers of serum antinuclear antibodies. Liver biopsy specimen showed histological features of primary biliary cirrhosis with marked cellular infiiltration of the portal areas and bile duct damage. Intralabular intlammation and piecemeal necrosis were mild. These patients were treated with prednisolone or UDCA and then, showed decrease in serum alkaline phosphatase level. We thought these patients were cornpatible with autoimmune cholangiopathy.

Keyword

Primary biliary cirrhosis; Autoimmune hepatitis; Autoimmune cholangiopathy

MeSH Terms

Alkaline Phosphatase
Antibodies
Antibodies, Antinuclear
Bile Ducts
Biopsy
Female
Fluorescent Antibody Technique
gamma-Glutamyltransferase
Hepatitis B
Hepatitis, Autoimmune
Humans
Liver
Liver Cirrhosis, Biliary
Necrosis
Prednisolone
Alkaline Phosphatase
Antibodies
Antibodies, Antinuclear
Prednisolone
gamma-Glutamyltransferase