Korean J Gastrointest Endosc.  1998 Apr;18(2):262-269.

A Case of Pseudomembraneous Colitis by Clostridium Perfringens

Affiliations
  • 1Department of Internal Medicine, School of Medicine, Catholic University of Taegu-Hyosung, Taegu, Korea.
  • 2Department of Clinical Pathology, School of Medicine, Catholic University of Taegu-Hyosung, Taegu, Korea.
  • 3Department of Surgical Pathology, School of Medicine, Catholic University of Taegu-Hyosung, Taegu, Korea.

Abstract

A 62-year-old female was adrnitted to the Catholic University Hospital of Taegu-Hyosung with an intracerebral hemorrhage. She was operated on successfully, but developed bacterial pneumonia. She was then treated with sulperazone, tobramycin, and metronidazole for 1 month. After the antibiotic treatment, she suffered from a fever and bloody, mucoid diarrhea for 3 days, and was examined with a sigmoidoscope. The sigmoidoscopic examination revealed yellow patches of ulcerations and swelling covered with thick sero- sanguinous exudate in the distal transverse colon and sigmoid colon. A latex agglutination test for C. was performed on her stool, whereby difficile cytotoxin was negative, however, metronidazole resistant C. perfringens was isolated from anaerobic culture of the biopsied colon tissue. She recovered with 15 days using oral vancomycin treatment. The possibility of C. perfringens as a causative organism of pseuclomernbraneous colitis was discussed.

Keyword

Pseudomembraneous colitis; C perfringens; Metronidazole
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