Korean J Gynecol Endosc Minim Invasive Surg.  2011 May;23(1):40-44.

The effectiveness of a single preoperative dose of misoprostol during laparoscopic myomectomy

  • 1Department of Obstetrics and Gynecology, Gangnam CHA Medical Center, CHA University School of Medicine, Seoul, Korea.


OBJECTIVE: To evaluate the effectiveness of single preoperative dose of misoprostol to reduce intraoperative hemorrhage during laparoscopic myomectomy.
We reviewed retrospectively the medical records of 148 patients who underwent laparoscopic myomectomy in Gangnam CHA Medical Center between January 2007 and December 2009 by single surgeon. Among them, 46 patients used preoperative transrectal misoprostol. One hundred two patients underwent laparoscopic myomectomy in conventional method without any preoperative agents.
The two groups were similar in baseline characteristics. There was no significant difference in mean blood loss (misoprostol group: 203.3+/-181.8 mL vs. no agent group: 207.7+/-144.5 mL), operation time (misoprostol group: 113.3+/-28.2 min vs. no agent group: 113.4+/-31.5 min), and hemoglobin change (misoprostol group: 2.0+/-1.0 g/dL vs. no agent group: 1.9+/-1.0 g/dL). Two patients needed transfusion in misoprostol group whereas none in control group, but there was no statistical significance.
A single preoperative dose of transrectal misoprostol cannot reduce bleeding during laparoscopic myomectomy.


Misoprostol; Laparoscopic myomectomy
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