Korean J Helicobacter Up Gastrointest Res.  2015 Mar;15(1):53-58. 10.7704/kjhugr.2015.15.1.53.

Case Series of Gastric Hepatoid Adenocarcinoma

Affiliations
  • 1Digestive Disease Center and Research Institute, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea. rock5014@schmc.ac.kr
  • 2Department of Pathology, Soonchunhyang University College of Medicine, Bucheon, Korea.
  • 3Department of Surgery, Soonchunhyang University College of Medicine, Bucheon, Korea.

Abstract

Hepatoid adenocarcinoma of the stomach (HAS) is a rare form of gastric cancer that histologically resembles hepatocellular carcinoma and is characterized by large amounts of alpha fetoprotein in the serum. The prognosis of HAS is poor compared to that of primary gastric cancer with five-year survival rates of 9% and 44%, respectively. Here, we report five patients diagnosed with HAS. Our experience suggests that an advanced stage of HAS has an extremely poor prognosis, but early detection and radical surgery can help improve the prognosis of the disease.

Keyword

Alpha-fetoproteins; Stomach neoplasms; Hepatoid adenocarcinoma; Prognosis

MeSH Terms

Adenocarcinoma*
alpha-Fetoproteins
Carcinoma, Hepatocellular
Humans
Prognosis
Stomach
Stomach Neoplasms
Survival Rate
alpha-Fetoproteins
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