Korean J Hepatobiliary Pancreat Surg.
2001 Jul;5(1):169-173.
Clinical Efficacy and Safety of Intravenous levofloxacin in Patients of Abdominal Operati
- Affiliations
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- 1Department of Surgery, College of Medicine, Yonsei University, Korea. wjlee@yumc.yonsei.ac.kr
Abstract
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BACKGROUND/AIMS: For the investigation of the efficacy and safety of intravenous levofloxacin, The clinical study was carrried out in 30 patients with abdominal operation, especially in hepatobiliary and pancreatic division.
METHODS
Randomly chosen patients received intravenous levofloxacin (250mg bid) for only 7 days. Clinical and microbiological evaluation were conducted on the day of starting and finishing levofloxacin treatmeat except for the case of combined use of antibiotics.
RESULTS
The most commonly isolated organism was staphylococcus aureus(33%, 3/9). The overall bacteriologic eradication rate was 67%, (6/9) with clinical success rate was 96%(29/30), There were no significant dverse effects to stop the administration of the drug.
CONCLUSION
These results suggest that intravenous levofloxacin is effective and safe antibiotics in the fields management of abdominal operation especially in hepatobiliary and pancreas surgery.
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