Korean J Med.
2010 Jul;79(1):77-81.
Autologous peripheral blood stem cell transplantation with high-dose therapy for anaplastic large cell lymphoma with progressive myelofibrosis
- Affiliations
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- 1Division of Hematology/Oncology and Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea. jykwak@chonbuk.ac.kr
- 2Division of Pathology, Chonbuk National University Medical School, Jeonju, Korea.
- 3Division of Laboratory Medicine, Chonbuk National University Medical School, Jeonju, Korea.
Abstract
- Myelofibrosis is a myeloproliferative neoplasm characterized by abnormal bone marrow megakaryocyte proliferation with reticulin and collagen fibrosis, leukoerythroblastosis, anemia, increased level of serum lactate dehydrogenase and splenomegaly. Myelofibrosis associated with malignant lymphoma is rare and survival rates appear to have been poor. Herein, we describe our experience in a patient who remained in complete remission with high-dose therapy (HDT) with autologous peripheral blood stem cell transplantation (PBSCT) for ALK-negative ALCL presenting with rapidly progressing myelofibrosis.
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