Korean J Nephrol.
2010 Nov;29(6):796-801.
Neurotoxicity Induced by Cefepime in a Patient with Minimal Change Disease
- Affiliations
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- 1Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. sbkim@amc.seoul.kr
- 2Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Abstract
- A 71-year-old woman with minimal change disease visited our clinic complaining of pleuritic chest pain. Cefepime was given under the impression that she had pneumonia. Three days after cefepime administration, she became unconscious. A brain MRI scan was non-revealing and an EEG showed triphasic waves. As there was no evidence of septic, uremic or hepatic encephalopathy, we suspected cefepime-induced neurotoxicity. Cefepime was stopped and she underwent hemodialysis to decrease the blood levels of the drug. Following hemodialysis, she regained consciousness.
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