Korean J Nephrol.  2001 Nov;20(6):1039-1042.

Minimal Change Nephrotic Syndrome Associated with Mesalazine Treatment in a Patient with Ulcerative Colitis

• Yang JO
• Kim SE
• Lee SJ
• Park KH
• Jang YK
• Suh KS
• Lee KW
• Shin YT

Abstract

Mesalazine has been widely prescribed for the treatment of inflammatory bowel disease. In renal disease associated with inflammatory bowel disease, nephrolithiasis and amyloidosis are most common, and obstructive uropathy, acute renal failure, glomerular abnormalities and interstitial nephritis due to drug may be occur. However, glomerulonephritis presenting as nephrotic syndrome in patients with ulcerative colitis is very rare. We present a case of minimal change nephrotic syndrome probably associated with mesalazine treatment in patient with ulcerative colitis. A 31-year-old man was admitted with generalized edema and proteinuria. He had been initially treated by sulphasalazine and then received mesalazine for 6 months, recently. Kidney biopsy revealed minimal change disease. Mesalazine was discontinued immediately and prednisolone(1 mg/kg, P.O.) was prescribed. Eight weeks after prednisolone treatment, proteinuria disappeared and patient recovered completely.

Keyword

Mesalazine; Minimal change disease; Ulcerative colitis; Proteinuria; Prednisolone

MeSH Terms

Acute Kidney Injury
Adult
Amyloidosis
Biopsy
Colitis, Ulcerative*
Edema
Glomerulonephritis
Humans
Inflammatory Bowel Diseases
Kidney
Mesalamine*
Nephritis, Interstitial
Nephrolithiasis
Nephrosis, Lipoid*
Nephrotic Syndrome
Prednisolone
Proteinuria
Sulfasalazine
Ulcer*
Mesalamine
Prednisolone
Sulfasalazine