Korean J Otolaryngol-Head Neck Surg.  2004 Jul;47(7):669-674.

Angiogenesis and Ki67 Expression in the Thyroid Tumor

• Tae K
• Kim KT
• Lee HS
• Park YW
• Kim TH
• Ahn YH

Abstract

BACKGROUND AND OBJECTIVES
Angiogenesis is the process of new blood vessel development from preexisting vessel. In many human solid tumor, the extent of angiogenesis is one of the most significant prognostic factors that can be used to predict the patient survival rate and metastasis. The aim of this study is to investigate the role of new blood vessel formation in the thyroid tumors. SUBJECTS AND METHOD: We analyzed the microvascular density and proliferation index in the 70 cases of thyroid tumors by double immunohistochemistry with anti-CD34 and anti-Ki67 antibody. The microvascular density and Ki67 index were compared with the clinical parameters such as sex, age, stage, tumor extension, cervical lymph node metastasis, and prognostic factors, which were obtained through the retrospective review of the medical records. RESULTS: The microvascular density and Ki67 index were higher in malignant tumors than in benign tumors. Higher microvascular density and Ki67 index were associated with tumor stage and increased risk of AMES, AGES and MACIS scores. CONCLUSION: The microvascular density and Ki67 index may serve as significant prognostic factors in the differentiated thyroid cancer.

Keyword

Thyroid neoplasm; Angiogenesis factor; CD34; Ki67s

MeSH Terms

Angiogenesis Inducing Agents
Blood Vessels
Humans
Immunohistochemistry
Lymph Nodes
Medical Records
Neoplasm Metastasis
Retrospective Studies
Survival Rate
Thyroid Gland*
Thyroid Neoplasms
Angiogenesis Inducing Agents