Korean J Otolaryngol-Head Neck Surg.  1999 Feb;42(2):193-196.

Localization of Cystic Fibrosis Transmembrane Conductance Regulator in Nasal Polyp Epithelial Cell

• Jang YJ
• Cho JH
• Lee JH
• Lee CH

Abstract

BACKGROUND AND OBJECTIVES: Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel protein that plays an important role in electrolyte and water transport, whose kinetics and localization are altered in cystic fibrosis (CF). Previous studies showed its presence in the apical domain of ciliated respiratory epithelial cells, and airway secretory glands. The purpose of this study was to characterize the localization of CFTR in the epithelium of nasal polyp of the subjects without phenotypic expression of cystic fibrosis. MAERIALS AND METHODS: Immunohistochemical staining for CFTR, using monoclonal mouse anti-human CFTR, were performed on tissue sections of 4 normal turbinate and nasal polyps from 10 patients who underwent intranasal operation.
RESULTS
The nasal polyp epithelium demonstrated a heterogeneous pattern of CFTR expressions, including diffuse or scattered cytoplasmic labeling, very low to undetectable labeling, intense perinuclear staining, and typical apical location.
CONCLUSION
These results suggest that abnormal expression and distribution of the CFTR may have a role in the formation of nasal polyp.

Keyword

Nasal polyp; CFTR

MeSH Terms

Animals
Chloride Channels
Cystic Fibrosis Transmembrane Conductance Regulator*
Cystic Fibrosis*
Cytoplasm
Epithelial Cells*
Epithelium
Humans
Kinetics
Mice
Nasal Polyps*
Turbinates
Chloride Channels
Cystic Fibrosis Transmembrane Conductance Regulator