Korean J Pediatr Infect Dis.  2010 Dec;17(2):67-73.

Clinical Characteristics and Antibiotic Resistance of Urinary Tract Infections in Children: Escherichia. coli Versus Non-E. coli

Affiliations
  • 1Departments of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. kjhan@catholic.ac.kr

Abstract

PURPOSE
We aimed to compare the clinical features and antibiotic resistance of urinary tract infection (UTI) caused by pathogens other than E. coli (non-E. coli) with UTI caused by E. coli in children.
METHODS
We enrolled patients with culture-proven UTI, who were admitted to the study hospital from September 2008 to August 2009. We investigated clinical data of patients with UTI and antibiotic resistance of isolated strains. For comparison, patients were divided according by results of the urine culture into E. coli and non-E. coli UTI groups.
RESULTS
A total of 84 patients participated in this study. Twenty one cases (25.0%) were caused by non-E. coli pathogens. Frequency of non-E. coli UTI differed according to age and sex: 'male <6 months', 10.5%; 'male > or =6 months', 50.0%; 'female <6 months', 43.7%; and 'female > or =6 months', 25.0% (P=0.014). More patients who received previous antibiotic treatment (P=0.017), but fewer patients who showed hematuria (P=0.014) were included in the non-E. coli UTI group than in the E. coli UTI group. Comparison of antibiotic resistance showed that the non-E. coli UTI group possessed more strains that were resistant to cefazolin, cefotaxime, imipenem, trimethoprim/sulfamethoxazole (TMP/SMZ) and tetracycline than the E. coli UTI group (P<0.05).
CONCLUSION
Increased incidence, different distribution by age and sex, and high antibiotic resistance of non-E. coli UTI should be considered in selection of empirical antibiotics for treatment of UTI in children.

Keyword

Urinary tract infections; Uropathogens; Drug resistance; Bacterial

MeSH Terms

Anti-Bacterial Agents
Cefazolin
Cefotaxime
Child
Drug Resistance
Drug Resistance, Microbial
Escherichia
Hematuria
Humans
Imipenem
Incidence
Tetracycline
Urinary Tract
Urinary Tract Infections
Anti-Bacterial Agents
Cefazolin
Cefotaxime
Imipenem
Tetracycline
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