Korean J Perinatol.  2010 Mar;21(1):40-47.

Associations of IGF-I, IGFBP-3 on early Catch-up Growth in Small for Gestational Age Infants

• Kang JW
• Han HY
• Lee JJ
• Choi JH
• Lee KS
• Chang MY

Abstract

OBJECTIVE
This study was aimed to analyze the effect of Insulin-like growth factor (IGF)-I and Insulin-like growth factor binding protein (IGFBP)-3 on early catch-up growth in small for gestational age (SGA) infants.
METHODS
We prospectively studied in 18 SGA infants who were admitted at Chungnam National University Hospital from January 2004 to January 2006. We divided them into two groups of intrauterine growth retardation; symmetric and asymmetric type. Maternal and neonatal characteristics and the value of IGF-1 and IGFBP-3 at birth were compared between the two groups. After 12 months later, we checked their body weight and height to evaluate catch-up growth.
RESULTS
Among 18 SGA infants, 5 were male and 13 were female. Average gestational age at birth was 38.4+/-1.1 weeks. Average birth weight was 2,359+/-154 g. Nine babies showed symmetric intrauterine growth retardation. Thirteen babies achieved catch-up growth at 12 month of age. There was no correlation between the characteristics of SGA and catch-up growth. However, the IGF-I and IGFBP-3 values were significantly higher in babies who showed catch-up growth.
CONCLUSION
We were able to predict catch-up growth at early infancy by evaluating serum IGF-I and IGFBP-3 values at birth in SGA infants.

Keyword

Small for gestational age; IGF-I; IGFBP-3; Catch-up growth

MeSH Terms

Birth Weight
Body Weight
Carrier Proteins
Female
Fetal Growth Retardation
Gestational Age
Humans
Infant
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Male
Parturition
Prospective Studies
Carrier Proteins
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I