Korean J Perinatol.  2006 Dec;17(4):391-396.

Clinical Consideration of Premature Twins Conceived by in Vitro Fertilization and those of Naturally Conceived

• Shin JH
• Nam HY
• Lee CA
• Choi EN
• Lee KH

Abstract

OBJECTIVE
The aim of this study was to evaluate and compare neonatal outcome of premature twins conceived by in vitro fertilization (IVF) to those of naturally conceived.
METHODS
We retrospectively analyzed neonatal outcome of sixty pairs of premature twins conceived by IVF (IVF twin group) and 34 pairs that naturally conceived (natural twin group). Maternal and obstetric characteristics were also compared. All were born before 35 weeks of gestation between January 2000 and December 2004 at Pochon-Cha Hospital and admitted to neonatal intensive care unit. Student t-test and chi-square test were used for statistical analysis.
RESULTS
For obstetrical characteristics, maternal age and rates of nulliparous were sibnificanty twin group. But, other parameters (preterm labor, premature rupture of membranes, pregnancy-induced hypertension, gestational diabetes mellitus) were similar between two groups. For neonatal outcome, gestational age, duration of hospital stay, Apgar score, neonatal mortality and morbidity were reviewed. All parameters were no significant differences in IVF twin group compare to natural twin group
CONCLUSIONS
In our study, IVF twin group had no significant differences in obstetric characteristics (except for maternal age and parity) and neonatal outcome compare to natural twin group.

Keyword

Premature twins; In vitro fertilization; Obstetric characteristics; Neonatal outcome

MeSH Terms

Apgar Score
Diabetes, Gestational
Female
Fertilization in Vitro*
Gestational Age
Humans
Hypertension, Pregnancy-Induced
Infant
Infant Mortality
Infant, Newborn
Intensive Care, Neonatal
Length of Stay
Maternal Age
Membranes
Obstetric Labor, Premature
Pregnancy
Retrospective Studies
Rupture
Twins*