Korean J Physiol Pharmacol.
2006 Apr;10(2):79-83.
The Effect of Dehydroepiandrosterone on Isoproterenol-induced Cardiomyopathy in Rats
- Affiliations
-
- 1Department of Pharmacology, School of Medicine, Chung Ang University, Seoul, Korea. jhjeong3@cau.ac.kr
- 2Department of Emergency Medicine, School of Medicine, Chung Ang University, Seoul, Korea.
- 3Department of Pathology, School of Medicine, Chung Ang University, Seoul, Korea.
Abstract
- We evaluated therapeutic and preventive properties of dehydroepiandrosterone (DHEA), a weak androgenic steroid, against isoproterenol-induced cardiomyopathy. The cardiomyopathy was induced by daily i.p. administration of isoproterenol to rats for five days. One group of rats were given with daily s.c. for 5 days during isoproterenol and the other group with daily s.c. DHEA for total 10 days, including 5 days before and during isoproterenol. The animals were killed after each treatment, and cardiac muscle failure was evaluated using histopathologic examination and biochemical indices. DHEA was found to reduce the damaged area and inhibit the elevation in the serum levels of glutamic oxaloacetic transaminase (SGOT), lactate dehydrogenase (LDH), skeletal muscle creatine kinase (CK) and heart creatine kinase (CK-MB) induced by isoproterenol. We also assayed widely used oxidative stress parameters, including thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase and glutathion peroxidase (GPx). DHEA decreased the escalated level of TBARS and enhanced the anti oxidant defense reaction with an increase in Mn-SOD and Cu/Zn-SOD. On the other hand, the treatment with DHEA did not affect catalase and GPx activity. The present study indicates that DHEA has a therapeutic and preventive effect against isoproterenol-induced cardiomyopathy and its effects may depend largely on the increase in SOD activity.
MeSH Terms
-
Animals
Aspartate Aminotransferases
Cardiomyopathies*
Catalase
Creatine Kinase
Dehydroepiandrosterone*
Hand
Heart
Isoproterenol
L-Lactate Dehydrogenase
Muscle, Skeletal
Myocardium
Oxidative Stress
Peroxidase
Rats*
Superoxide Dismutase
Thiobarbituric Acid Reactive Substances
Aspartate Aminotransferases
Catalase
Creatine Kinase
Dehydroepiandrosterone
Isoproterenol
L-Lactate Dehydrogenase
Peroxidase
Superoxide Dismutase
Thiobarbituric Acid Reactive Substances
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