J Vet Sci.  2014 Dec;15(4):583-586. 10.4142/jvs.2014.15.4.583.

Detection of Corynebacterium bovis infection in athymic nude mice from a research animal facility in Korea

Affiliations
  • 1Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea. pjhak@snu.ac.kr
  • 2BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
  • 3Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 110-799, Korea.
  • 4Department of Biochemistry, College of Medicine, Konyang University, Daejeon 302-832, Korea.

Abstract

Corynebacterium (C.) bovis infection in nude mice causes hyperkeratosis and weight loss and has been reported worldwide but not in Korea. In 2011, nude mice from an animal facility in Korea were found to have white flakes on their dorsal skin. Histopathological testing revealed that the mice had hyperkeratosis and Gram-positive bacteria were found in the skin. We identified isolated bacteria from the skin lesions as C. bovis using PCR and 16S rRNA sequencing. To the best of our knowledge, this is the first report of C. bovis infection in nude mice from Korea.

Keyword

athymic nude mice; Corynebacterium bovis; hyperkeratosis
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