Yonsei Med J.  2014 Nov;55(6):1453-1466. 10.3349/ymj.2014.55.6.1453.

Helicobacter pylori: Bacterial Strategy for Incipient Stage and Persistent Colonization in Human Gastric Niches

• Rhee KH
• Park JS
• Cho MJ

• KMID: 2070191
• DOI: http://doi.org/10.3349/ymj.2014.55.6.1453

Abstract

Helicobacter pylori (H. pylori) undergoes decades long colonization of the gastric mucosa of half the population in the world to produce acute and chronic gastritis at the beginning of infection, progressing to more severe disorders, including peptic ulcer disease and gastric cancer. Prolonged carriage of H. pylori is the most crucial factor for the pathogenesis of gastric maladies. Bacterial persistence in the gastric mucosa depends on bacterial factors as well as host factors. Herein, the host and bacterial components responsible for the incipient stages of H. pylori infection are reviewed and discussed. Bacterial adhesion and adaptation is presented to explain the persistence of H. pylori colonization in the gastric mucosa, in which bacterial evasion of host defense systems and genomic diversity are included.

Keyword

Helicobacter pylori; gastric infection; persistent colonization; pathogenesis

MeSH Terms

Gastric Mucosa/*microbiology
Gastritis/*microbiology/pathology
Helicobacter Infections/*microbiology
Helicobacter pylori/*physiology
Humans
Stomach Neoplasms/pathology

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