J Bacteriol Virol.  2015 Sep;45(3):179-188. 10.4167/jbv.2015.45.3.179.

Influence of the Host Factors on Human Papillomavirus Infection and Vaccine Efficacy

• Sohn SH
• Nam JH

• KMID: 2068733
• DOI: http://doi.org/10.4167/jbv.2015.45.3.179

Abstract

Human papillomavirus (HPV) is associated with cervical cell changes, genital warts, recurrent respiratory papillomatosis, laryngeal papillomatosis, head and neck cancer, and cervical cancer. Two commercial HPV vaccines have successfully been made available in the clinical field. This review covers the progress of cervical disease by understanding the nature of HPV infection, as well as the relationship between the host factors and HPV vaccine effectiveness. Among these host factors, microbiota has been revealed to influence the development and function of both the innate and adaptive immune systems. Therefore, the composition of the microbiome may ultimately affect vaccine efficacy. Understating the relationship between host factors and HPV infection/vaccine efficacy may prove to be useful in earlier diagnosis, as well as disease prophylaxis.

Keyword

HPV; Vaccine efficacy; Probiotics; Microbiota

MeSH Terms

Condylomata Acuminata
Diagnosis
Head and Neck Neoplasms
Humans*
Immune System
Microbiota
Papilloma
Papillomavirus Infections*
Papillomavirus Vaccines
Probiotics
Uterine Cervical Neoplasms
Papillomavirus Vaccines